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» Solandelactone E
06/09/10 20:13 from TotallySynthetic.com
Aggarwal, Robinson. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201003236 A question – how long does one spin-out natural products based on one particular method? I ask this as this is the second synthesis I've written about this year..
» Manzamine A
06/09/10 20:13 from TotallySynthetic.com
Fukuyama, Toma, Kita. JACS, 2010, ASAP. DOI: 10.1021/ja103721s Ah – now this is a bit of a blast-from-the-past. I knew I'd written something about this molecule before, so I had a quick rummage in the Tot. Syn. folder on my PC ̵..
» Cortistatins A (J, K and L) Pt. IV
06/09/10 20:13 from TotallySynthetic.com
Myers, Flyer, Si. Nat. Chem., 2010, AOP. DOI: 10.1038/nchem.794 Cortistatin is one of those targets like platensimycin that has attracted an almost unhealthy synthetic lust in the last few years, with three previous appearances in these in..
» Dictyosphaeric Acid A
06/09/10 20:13 from TotallySynthetic.com
This month's Chemistry World piece is a rather nice synthesis of Dictyosphaeric Acid A by Richard Taylor's group in York.
» Galbulimima Alkaloids (-)-GB 13 and (+)-GB 16
06/09/10 20:13 from TotallySynthetic.com
Ma, Zi, Yu. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201002299. Why make one natural product when you can make two just as easily? Or three in this case, but the headline syntheses are the Galbulimima Alkaloids GB-13 and GB-16 – no..
» Urechitol A
06/09/10 20:13 from TotallySynthetic.com
Watanabe, Sumiya, Ishigami. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201002505. [No SI available] As much as biological activity is a great rationale for working on a molecule, I do like it when a group does the chemistry for the chemistr..
» Aplykurodinone 1
06/09/10 20:13 from TotallySynthetic.com
This month's Chemistry World column is Aplykurodinone 1, a rather neat Danishefsky synthesis.
» Fastigiatine
06/09/10 20:13 from TotallySynthetic.com
Shair, Liau, JACS, 2010, ASAP DOI: 10.1021/ja104575h. After wading through the Heathcock paper last week, I'm glad that today's topic of discussion is a little shorter and easier to read. (Seriously, part of me hates reading paper older t..
» Fawcettimine
06/09/10 20:13 from TotallySynthetic.com
Jung, Chang, Org. Lett., 2010, ASAP DOI: 10.1021/ol1009762. Although the number of actual steps in a formal synthesis is (or at least should be) smaller than in a full total-synthesis, I often feel that the actual work is harder. Afterall..
» Englerin A
06/09/10 20:13 from TotallySynthetic.com
Nicolaou, Chen, Kang, Ng, JACS, 2010, ASAP DOI: 10.1021/ja102927n. Another popular target today; a last month I wrote a piece in Chemistry World about the first two syntheses of this target, and only a month later, up-pops Nicolau and Chen..
» Addendum – The Vocational Bachelors Degree in Chemistry
06/09/10 18:50 from The Chemportal
The vocational Bachelors degree in Chemistry should be devised for people who wish to obtain their degree and be employed in the industry right away, rather than go on to graduate school. It is designed to increase..
» A Final Note On the Merits of a Bachelors degree in Chemistry
06/09/10 18:50 from The Chemportal
Please refer to the previous post to understand where all of this stemmed from. As for the final note on this thread I would like to make a few pointers as well as acknoweldgements based on the comments that have transpired. I should ..
» A Note To All Undergraduates Who Wish To Pursue A Degree In Chemistry
06/09/10 18:50 from The Chemportal
...Academia is obvlious to the industry, there is no official relationship or connection between the two (The following refers to the situation in the state of Georgia.). Don't enroll in Chemistry unless you plan to go..
» Exposure to Chemicals and Suicide Rates
06/09/10 18:50 from The Chemportal
At my previous job as an entry level process chemist there were times where people who were "high" on the corporate ladder would visit the pilot lab to assess its development and make certain that the site was properly situated for what wo..
» Grad school “Second Life – style ” . Going to graduate school in New York while in Georgia.
06/09/10 18:50 from The Chemportal
This guy at my workplace is going to grad school in New York while working here in Georgia , the company pays for his tuition and he gets video lecture material all through the net , his major is in chemical engineering , and it seems that..
» The not so ordinary properties of phosphate buffer
06/09/10 18:50 from The Chemportal
Part of an extraction procedure that's employed requires phosphate buffer as the solvent for one of the steps (extraction procedure is confidential). Now, I never had problems with it before , and had been making it for several month..
» My final trip back to the University
06/09/10 18:50 from The Chemportal
A few days ago, I took the trip back to the University to have that special talk with the professor once more, so that I could finally obtain the grade for the last of the courses that I took for an ACS certified Bachelors Degree in Chemis..
» Science professors have green and rotting teeth
06/09/10 18:50 from The Chemportal
Is it because some of them don't smile? A lot of coffee? Probably the combination of both .... without brushing their teeth. Yes , a lot of science professors, especially the old fashioned ones (some of them a..
» The future of biochemistry: the biochemistry of psychology
06/09/10 18:50 from The Chemportal
During the period that one of my last courses, biochemistry, was in session, I remember an occasion where I had stopped by the professor's office to point out an error in the grading of a test. He was friendly, in a very excitable mo..
» More preferable to Chemists….Nature or Science magazine?
06/09/10 18:50 from The Chemportal
I remember reading Kary Mullis' autobiography and a chapter from this book describing the event of getting a physics article published in Nature , despite the fact that he was a chemist. Kary Mullis was..
» Cursed Pine Nuts or Triglycerides?
06/09/10 16:55 from Just Chromatography
A few days ago I noticed that my taste was disturbed: no matter what I eat or drink I feel the bitter taste in my mouth. This bitter, metallic taste appears within seconds of chewing and it affects everything I eat even sweets! Initially I ..
» Forensic Application of Gas Chromatography
06/09/10 16:55 from Just Chromatography
These days gas chromatography (GC) is one of the primary analytical techniques used in every forensic laboratory. GC is widely used by forensic scientists - from analysis of body fluids for the presence of illegal substances, to testing of..
» Heat Flow through Hydrocarbon Chains
06/09/10 16:55 from Just Chromatography
Scientists have measured heat conduction through a monolayer of hydrocarbon chains using a novel technique. Researchers understand heat transfer on the scales of individual molecules and in solids, but there is still much to learn about the..
» Nano LC Sensitivity
06/09/10 16:55 from Just Chromatography
In theory, the analyte sensitivity increases on decreasing the column inner diameter; however, because of the very low sample volumes injected - 20-60 nL, nano liquid chromatography cannot be considered as an analytical method of high sensi..
» “Fast” HPLC better than UHPLC
06/09/10 16:55 from Just Chromatography
Research scientists from Schering-Plough Research Institute developed a rapid high-performance liquid chromatography (HPLC) technique that allows for efficient separation and analysis of pharmaceutical compounds. The method uses a short col..
» Fishy Chromatography
06/09/10 16:55 from Just Chromatography
Folks from India extracted 99.6% pure eicosapentaenoic acid (EPA) using silver ion (argentation) column chromatography from hydrolyzed sardine oil[1]. EPA and DHA (docosahexaenoic acid) are the two main long-chain polyunsaturated fatty aci..
» Columns for Gas Chromatography: Performance and Selection
06/09/10 16:55 from Just Chromatography
Choosing the right column is key in Gas Chromatography. "Columns for Gas Chromatography: Performance and Selection" is a new hands-on reference for scientists and technicians working with packed column and capillary column gas chromatograp..
» Motor Proteins in Nanotechnology
06/09/10 16:55 from Just Chromatography
The biological cell is basically a miniature factory, which contains a large collection of dedicated protein machines. In a Review, Martin van den Heuvel and Cees Dekker look at recent progress in using some of these proteins to move, mani..
» The Little Botanists
06/09/10 16:55 from Just Chromatography
I am continuing the series dedicated to the chromatography??s founder Mikhail Tsvet. So, in 1897 he moves to Russia from Switzerland, and here is his first impression of Russia: "...during the first six months that I have been in Russia, in..
» Unanswered Questions
06/09/10 16:55 from Just Chromatography
Today I studied my blog's statistics to see what keywords people use to search in Google and Yahoo! to get to the pages of my site. Here is what I found based on the last 60 days of statistics: People used 1966 various search terms The top ..

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Out with the old fucking ball sucker, in with the new fucking ball sucker. The nightmare has not yet begun.
2000: “Oh, Bush can’t be THAT bad.”
2008: “God, I hope Obama isn’t THAT bad.”
The past eight years have left me way too cynical about the executive branch- I don’t know what, if anything, the Obama administration will fix. That said, I’m not giving up all hope, like many have for whatever reason. But let’s start to see change instead of hear about it.
I’m not sure I’ve even heard about any change yet; Obama plans to continue Bush’s bailout packages, expand Bush’s economic stimulus tax refund, continue and expand the failed war on terror into Afghanistan and Pakistan…
Even his approaches to good things, like increased community service, are backwards – the desire to help out the community should come from the grassroots, not come from above. A nationwide website to coordinate service will never be as responsive to real local needs as going to your community center and finding out what needs to be done. And a $4000 college credit for service? Basically, college tuitions will rise to match this subsidy and service will become voluntary for the rich and mandatory for the poor.
It’s okay though, he’s going to get the money for this by inflating the currency, which will create many, many more poor people to start filling up these service spots.
I guess the question would be whether Obama and the Dems can create poor people faster than W and the ‘pubs have, because that would seem to be a pretty amazing achievement at this point. That would seem to be the only thing that W and the ‘pubs were cost-efficient at creating.
Now that they’re gone, I’m going to be left wondering if the ‘pubs could have made Brazil into a documentary, if only they’d been given more time.
Hey, let’s get things straight here. Bush’s destruction of the economy was at the hands of the Keynesian, liberal notion that devaluing the currency can be used to drive the economy, that spending drives business and job creation. Remember after 9/11: “go back and keep shopping”? That’s a liberal concept.
Sure, Bush mixed in a strong heaping of corporatist “trickle down” concepts. But even this, is not truly conservative. Just elitist. True conservatives want no taxes for everyone, rich and poor, no government-driven inflation for everyone, and actually espouse a pacifist doctrine.
Remember, FDR, liberal de jour, and inspiration to Obama, was responsible for the wholesale, racist lockup of 50k+ citizens without due process, confiscated individual, private gold holdings from safety deposit boxes (no shit), and created the notion of defecit spending.
Dear Darksyde,
I think I speak for all of us when I say, please shut up.
Sincerely,
The Chemistry Blogosphere
Done.
See you folks later.
Could it be true? At least Uncle Al is interesting…
He’s not that interesting. More unhinged, though. Nihilism is so 1880’s anyway.
True, but in the long time I’ve seen Uncle Al post, there is always the entertainment factor in trying to figure out what the heck he is saying.
Like solving a puzzle.
You don’t speak for all of us.
I appreciate your cynicism and, though it’s horribly cliche, I can’t really summarize the last 8 years of Bush’s reign any better than the YeTube video below of Olbermann. Simply doing better than this isn’t an option and isn’t hard. Obama has his work cut out for him if he wants to fix shit – but doing “better than Bush” is a comparatively easy task.
in 2000, Bush ran on a platform of smaller government and non-interventionism, railing against Clinton’s misadventures in Yugoslavia, his bombing of sudan, etc.
Don’t worry, this is a beginning of a new, profoundly different error.
Actually, I’m really impressed with the new marine sanctuary. Bush did a very good thing with that and since I just watched “The Blue Planet” as narrated by David Attenborough, I forgive Bush for everything else that has happened. Humans don’t matter in the exciting world of atolls, mantis shrimp and the blue whale.
Actually this was done by Linda Lingle before Bush.
http://www.ens-newswire.com/en.....-30-04.asp
I’m not sure what the effective difference between the 3 mi state waters and the 200 mile EEZ is; most of the reef fish are within 3 miles; although I suppose some monk seals transit between the islands.
How long before one of Bush’s brothers, or, (gah!) one of Bush’s daughters becomes president?
Dave
Jeb Bush is uncannily good – he used to be the governor here in Florida, and Florida has been a fairly well-run state. I would vote for Jeb Bush without hesitation, he is a smooth operator and he dislikes to bluster. And he has been one of the main advocates of using the state’s surplus money for bringing Scripps and Max Planck institutes to Florida – these were not modest sums, Florida is going to spend something close to 1 billion total in its attempt to jump-start its biotech.
well spoken and true. i no longer reside in the sunshine state but would support jebs efforts in a heartbeat…
I sincerely hope we’re done with famous relatives trying to be politicians. I’m looking at you, Caroline Kennedy.
But I’m a member of a famous family! Isn’t that enough?
Fuck no. Get the hell out and go back to compiling books of poetry.
There once was a woman from Nantucket
Whose granddad brought over liquor in a bucket
She’s really smart
And doesn’t fart (much)
In addition, she hasn’t become a crook yet.
PleasePleasePlease send me to the Senate. Please?
No.
I guess you agreed with me.
Link here: http://www.nytimes.com/2009/01.....r=1&hp
Looks like Governor Paterson decided to go with someone with no serious political family ties.
Sounds like she’s pretty conservative for a Democrat — interesting to see if people view this as half a loaf.
My dad was governor of new york for how long? Well, whatever. Vote for me!
Go screw yourself. Our country doesn’t typically have a nobility and our experiments with such, I think, haven’t worked out very well.
I would support getting all famous family members together (Bushes, Clintons, Kennedys, Reagans), dosing them with alcohol, Viagra and acid and taking pictures of the results. Surely with this blackmail material, we can keep them out of politics forever.
*cough*
Yes, Mr. President, your son did okay, lost to Andy Jackson. I think our more recent experience will color all of our judgments much more than your family’s history.
For that, I apologize.
I am sure those pictures are already around somewhere
At least in fan fic form
Almost half of the country voted for W, even when it was clear that he, his administration, and the party that supported him were dishonest and that he and the people he chose were unable to run a picnic without serious injury. Republicans have continued to get elected for their spend-and-spend policies even when it has become clear (after the inflation of the deficit under Reagan and then W) that the only thing their policy may be good for is to destroy the ability of the federal government to exist. (Want state governments running things? Look at your credit cards to see where that will end up – high rates, no protections for customers – because that’s what happens when states compete for businesses. But, hey, the banks are making out. Right?) People want lower taxes but have no idea how to pay for what they do want – we seem to be hoping our debts will magically disappear (without costing us our paychecks, of course). W was elected to implement the policy of aggressively ignoring unpleasant realities in the hope that they will thereby will go away.
None of these factors has changed upon the election and inauguration of Obama. If we can’t face the consequences of what we want and are unwilling to consider anyone but ourselves, then we’re not going to be around for very long. Obama may be competent (at least more so than the W) but he can’t unmake reality, and if that’s what we want we are going to be disappointed.
I think ultimately half the country voted for W because the chief contender didn’t look like he would run anything any differently. So might as well stick with the Jackass you know. As bad as W’s 2nd term has been, I honestly can’t think Kerry would have been any better. The housing bubble was already inevitable and predicted by non-Keynesian economists by mid-2004.
Well, don’t know if you’ll see this, but…
I don’t this W’s execution has been all that competent, and I think either Gore’s or Kerry’s would have been better. I don’t think Gore or Kerry would have had as blatant a disrespect for the law or Congress (signing statements?) as W’s admin. Depending on Congress’s composition, I don’t think Gore or Kerry would have thrown as much money away (while the Dems may have invented deficit spending, they raised taxes to pay for it, unlike Reagan, W, et al. who have mostly just spent and pretended that “the magic of the market” would take care of the debt). We also probably would be able to deal better with Russia and the Middle East (though this is iffy – Clinton mostly ignored Russia, I think, and that’s part of the problem, but W has helped create a vacuum that Russia would love to fill). The fact that Democrats have done lots of bad things doesn’t mean that they are not a better alternative. (Two words to strike fear into the hearts of (almost) all: President Palin.)
Ultimately, W was the expression and endorsement of people’s unwillingness to deal with reality. The Dems could not (and probably would not) have made that go away, but they would probably not have given flight to the worst of Bush/Cheney’s fantasies. I don’t lay 9/11 or the economic collapse on W (though his ethos of “the markets will regulate themselves” couldn’t have helped), but his execution and inability to understand his oath of office make the number of alternatives who couldn’t do a better job rather limited.
I agree. As Obama himself said today, people need to take hard decisions and act accordingly. Unfortunately the overriding goal of American capitalism is to keep feeling good about yourself. The people need to take charge of their situation and that includes hunkering down and making some difficult choices. Otherwise no President can do anything.
I was taken aback by the TV anchors who were explaining that “Obama has two balls tonight” before I figured what they were talking about.
Then in his speech Obama exhorted us that “Our journey has never been… the path for the faint-hearted” which immediately reminded me “The World is not here to be possessed by the faint-hearted races” by another man, famously having one ball only.
And there’s the Hitler reference. Thank you, Goodnight.
Seriously… this being a chemistry blog how has no one really gone off on Bush’s butchering of science policy? Instead of using science to guide policy the fuckhole used policy to guide science!
You people need to snap out of your goddamn cynicism and grasp onto the hate. This isn’t about irrationally hating a guy because an overwhelming number of people do, it’s about hating him for very specific reasons near and dear to our hearts. If you can’t summon the rage against a man that doesn’t even hold power any more, how are you going to focus your anger pointedly when Obama starts fucking up?
Since Uncle Al hasn’t graced us with his presence I’ll channel him:
W’s butchering of science is a minor expression of the general Republican theory of “if we ignore reality hard enough it will go away”. While his science policies suck rancid ass, I think the consequences of his policies to the federal budget (I am being optimistic in assuming the Republicans weren’t intending to bankrupt the federal government so business can take over, instead), the Constitution, regulatory abilities, and the economy are all significantly worse than those to science. There’s too much to dislike from his policies for me to work all the way down to his science policy.
Most of the problems with science involve the magic of the market – the inability of businesses to generate viable products without actually paying anyone to do research. Outsourcing works at increasing short-term profit but neither increases research productivity here nor solves the problems of not knowing what research to do or how to do it effectively. Eventually it trains your competitors overseas, and provides significant disincentives to be a scientist in the US. Science had a policy article on “Structural Disequilibria in Biomedical Research” in Aug. ‘08(?)- it seemed to say (if I’m correct) that we are already training too many people for academic jobs that don’t exist, and if many of the business jobs leave as well, there isn’t much reason to be a scientist (people should do something that they love, but spending lots of money training people for jobs that don’t exist might not be a good idea).
As I said, I don’t really hate him. Now that I think about it, he was mostly a bad president, but making a giant marine national park ameliorates my intense dislike somewhat. Surely there is some scientific research that can be done there in the marine park? I watched all the marine specials that I can rent on Netflix already… I wish I had gone into biology. Today I had a dream that I was piloting a deep sea research sub in the trench that became part of the park. Apparently it’s a really competitive field though.
Also, I was really mad about Iraq from 2004-2008, but now not so much. Even though it was wrong, 20 years from now it’ll be seen as a positive development for the region and that country. In a Machiavellian sort of way. On the other hand, Afghanistan was never a developed country with a well-educated populace, so it could end very badly there.
His science policy also could have been a lot worse. On the whole, it was nothing that was not unexpected from his administration by me. I was actually surprised that it was not worse. Overall, America’s science funding is still really high and I suppose it could be higher in relation to the military budget, but it’s not that bad. We’re better off than the vast majority of the world.
Of course if Global Warming happens and we all die, then I’ll seriously be pissed off at Bush. I’m making future plans with a view that I’ll live for now.
He has lied left right and center to everyone including myths of all of us dying form Saddam’s weapons and now he goes free to enjoy his expensive retirement after 8 years of talking with God. How can this happen?