» Solandelactone E
10/09/10 19:25 from TotallySynthetic.com
Aggarwal, Robinson. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201003236 A question – how long does one spin-out natural products based on one particular method?  I ask this as this is the second synthesis I've written about this year..

» Manzamine A
10/09/10 19:25 from TotallySynthetic.com
Fukuyama, Toma, Kita. JACS, 2010, ASAP. DOI: 10.1021/ja103721s Ah – now this is a bit of a blast-from-the-past.  I knew I'd written something about this molecule before, so I had a quick rummage in the Tot. Syn. folder on my PC ̵..

» Cortistatins A (J, K and L) Pt. IV
10/09/10 19:25 from TotallySynthetic.com
Myers, Flyer, Si. Nat. Chem., 2010, AOP. DOI: 10.1038/nchem.794 Cortistatin is one of those targets like platensimycin that has attracted an almost unhealthy synthetic lust in the last few years, with three previous appearances in these in..

» Dictyosphaeric Acid A
10/09/10 19:25 from TotallySynthetic.com
This month's Chemistry World piece is a rather nice synthesis of Dictyosphaeric Acid A by Richard Taylor's group in York.

» Galbulimima Alkaloids (-)-GB 13 and (+)-GB 16
10/09/10 19:25 from TotallySynthetic.com
Ma, Zi, Yu. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201002299. Why make one natural product when you can make two just as easily?  Or three in this case, but the headline syntheses are the Galbulimima Alkaloids GB-13 and GB-16 – no..

» Urechitol A
10/09/10 19:25 from TotallySynthetic.com
Watanabe, Sumiya, Ishigami. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.201002505. [No SI available] As much as biological activity is a great rationale for working on a molecule, I do like it when a group does the chemistry for the chemistr..

» Aplykurodinone 1
10/09/10 19:25 from TotallySynthetic.com
This month's Chemistry World column is Aplykurodinone 1, a rather neat Danishefsky synthesis.

» Fastigiatine
10/09/10 19:25 from TotallySynthetic.com
Shair, Liau, JACS, 2010, ASAP DOI: 10.1021/ja104575h. After wading through the Heathcock paper last week, I'm glad that today's topic of discussion is a little shorter and easier to read.  (Seriously, part of me hates reading paper older t..

» Fawcettimine
10/09/10 19:25 from TotallySynthetic.com
Jung, Chang, Org. Lett., 2010, ASAP DOI: 10.1021/ol1009762. Although the number of actual steps in a formal synthesis is (or at least should be) smaller than in a full total-synthesis, I often feel that the actual work is harder.  Afterall..

» Englerin A
10/09/10 19:25 from TotallySynthetic.com
Nicolaou, Chen, Kang, Ng, JACS, 2010, ASAP DOI: 10.1021/ja102927n. Another popular target today; a last month I wrote a piece in Chemistry World about the first two syntheses of this target, and only a month later, up-pops Nicolau and Chen..

» Cockroach Brains, Coming to a Pharmacy Near You
10/09/10 17:58 from Wired Science
Cockroaches may be nasty bugs, but they could help fight even nastier ones. New research finds that the rudimentary brains of cockroaches and locusts teem with antimicrobial compounds that slay harmful E. coli and MRSA, the antibiotic-resi..

» rubrene!
10/09/10 17:56 from Carbon-Based Curiosities
Here are some GIANT rubrene crystals I grew a while back.  Rubrene pretty much crystallizes (from vapor) if you sneeze at it.

» Cursed Pine Nuts or Triglycerides?
10/09/10 16:55 from Just Chromatography
A few days ago I noticed that my taste was disturbed: no matter what I eat or drink I feel the bitter taste in my mouth. This bitter, metallic taste appears within seconds of chewing and it affects everything I eat even sweets! Initially I ..

» Forensic Application of Gas Chromatography
10/09/10 16:55 from Just Chromatography
These days gas chromatography (GC) is one of the primary analytical techniques used in every forensic laboratory. GC is widely used by forensic scientists - from analysis of body fluids for the presence of illegal substances, to testing of..

» Heat Flow through Hydrocarbon Chains
10/09/10 16:55 from Just Chromatography
Scientists have measured heat conduction through a monolayer of hydrocarbon chains using a novel technique. Researchers understand heat transfer on the scales of individual molecules and in solids, but there is still much to learn about the..

» Nano LC Sensitivity
10/09/10 16:55 from Just Chromatography
In theory, the analyte sensitivity increases on decreasing the column inner diameter; however, because of the very low sample volumes injected - 20-60 nL, nano liquid chromatography cannot be considered as an analytical method of high sensi..

» “Fast” HPLC better than UHPLC
10/09/10 16:55 from Just Chromatography
Research scientists from Schering-Plough Research Institute developed a rapid high-performance liquid chromatography (HPLC) technique that allows for efficient separation and analysis of pharmaceutical compounds. The method uses a short col..

» Fishy Chromatography
10/09/10 16:55 from Just Chromatography
Folks from India extracted 99.6% pure eicosapentaenoic acid (EPA) using silver ion (argentation) column chromatography from hydrolyzed sardine oil[1]. EPA and DHA (docosahexaenoic acid) are the two main long-chain polyunsaturated fatty aci..

» Columns for Gas Chromatography: Performance and Selection
10/09/10 16:55 from Just Chromatography
Choosing the right column is key in Gas Chromatography. "Columns for Gas Chromatography: Performance and Selection" is a new hands-on reference for scientists and technicians working with packed column and capillary column gas chromatograp..

» Motor Proteins in Nanotechnology
10/09/10 16:55 from Just Chromatography
The biological cell is basically a miniature factory, which contains a large collection of dedicated protein machines. In a Review, Martin van den Heuvel and Cees Dekker look at recent progress in using some of these proteins to move, mani..

» The Little Botanists
10/09/10 16:55 from Just Chromatography
I am continuing the series dedicated to the chromatography??s founder Mikhail Tsvet. So, in 1897 he moves to Russia from Switzerland, and here is his first impression of Russia: "...during the first six months that I have been in Russia, in..

» Unanswered Questions
10/09/10 16:55 from Just Chromatography
Today I studied my blog's statistics to see what keywords people use to search in Google and Yahoo! to get to the pages of my site. Here is what I found based on the last 60 days of statistics: People used 1966 various search terms The top ..

» Polymer Solar Cells Build for Two
10/09/10 16:55 from Just Chromatography
Researchers have developed a new method for producing tandem solar cells, in which two solar cells working together to use a wider range of the solar spectrum. The physical properties of the semiconductor materials in each cell allow one t..

» Asparagusic Acid, Anyone?
10/09/10 16:55 from Just Chromatography
Thank God for Greg's post "Odeur d'Asperge" over at Carbon Tet! The mystery is solved, and I thought my kidneys were failing and I would have to spend the rest of my life on dialysis. This spring I had become an avid admirer of the young as..

» Nanogenerators Powered By Heartbeat
10/09/10 16:55 from Just Chromatography
Scientists from Georgian Institute of Technology created a prototype nanogenerator that can generate electricity inside a human body. Tiny little devices traveling in our bloodstream while performing complete blood analysis and monitoring ..

» High Reactivity at Very Low Temperatures
10/09/10 16:55 from Just Chromatography
New research examines a class of reactions between neutral free radicals and neutral molecules that, unlike most reactions, happen rapidly at very low temperatures. Chemical reactions generally accelerate when temperature increase. However,..

» Cocaine Pollution
10/09/10 16:55 from Just Chromatography
Cocaine is presently the most abused substance in Americas; however, the stimulant is gaining new advocates at an alarming rate in western Europe as well. In 2005, a group of researches from Italy analyzed water samples from the Po River in..

» Columns in Nano LC
10/09/10 16:55 from Just Chromatography
As I mentioned in the last post from this series, capillary columns of 10–100 μm inner diameter are commonly used in nano-liquid chromatography setups. They are typically made either from fused silica or PEEK materials currently ..

» Carbon Nanoscrolls to Store Hydrogen
10/09/10 16:55 from Just Chromatography
As our planet is running out of petroleum resources, a new energy source must be found. Hydrogen is regarded as an ideal alternative to fossil fuel because of its abundance in environment, renewability, and zero emission. However, the most ..

» Translational vs Vibrational
10/09/10 16:55 from Just Chromatography
Has anyone seen today's issue of Science? There is a research paper by Shannon Yan and colleagues "Do Vibrational Excitations of CHD3 Preferentially Promote Reactivity Toward the Chlorine Atom?" I had a difficult time following the authors ..