» Phostriecin and/or Sultriecin
09/02/10 11:02 from TotallySynthetic.com
Boger, Burke, Haq. JACS, 2010, ASAP. DOI: 10.1021/ja9097252. Figured it out already?  I bet it caused a few scratched-heads in Dale Boger's group when, having made the published structure for Sultriecin, things didn't tally-up.  We've disc..

» Crambidine
09/02/10 11:02 from TotallySynthetic.com
Gin, Perl, Ide, Prajapati, Perfect, Duron. JACS, 2010, ASAP. DOI: 10.1021/ja910831k. When I see targets containing guanidine moieties these days, I immediately think of David Gin, which goes to show how much he owns that motif just now.  L..

» Hyperforin
09/02/10 11:02 from TotallySynthetic.com
Shibasaki, Kanai, Shimizu, Shi, Usuda. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.200906678. ; Shibasaki, Kanai, Kuramochi, Usuda. Org. Lett., 2004, 6, 4387. DOI: 10.1021/ol048018s.  Three amazingly tough targets completed in (almost) as ma..

» Piperkadsin C [Isolation] – Updated
09/02/10 11:02 from TotallySynthetic.com
Lee, Kim, Choi, Ha, Kim. BOMCL, 2010, 20, 409-412. DOI: 10.1016/j.bmcl.2009.10.016. The Tot. Syn. bull-shit detector is at eleven just now, having just read Derek Lowe's post on Piperkadsin C.  This natural product was isolated by Kang Ro ..

» Isatisine A
09/02/10 11:02 from TotallySynthetic.com
Kerr, Karadeolian. ACIEE, 2010, EarlyView. DOI: 10.1002/anie.200906632. It's always going to be a tough situation for the article I blog following something like Palau'amine, but this short and sweet synthesis by Michael Kerr of the Univer..

» Palau'amine
09/02/10 11:02 from TotallySynthetic.com
Baran, Seiple, Su, Young, Lewis and Yamaguchi. ACIEE, 2009, EarlyView. DOI: 10.1002/anie.200907112. Y'know, I was kinda hoping for a bit of break between blog-posts this winter, as the amount of online publications tends to tail-off around..

» (iso)Bongkrekic Acid
09/02/10 11:02 from TotallySynthetic.com
Ley, Francais, Leyva, Etxebarria-Jardi. Org. Lett., 2009, ASAP. DOI: 10.1021/ol902676t. For those UKian readers out there, there's a fittingness to my posting a Cambridge paper following an Oxford last week.  Having spent a bit of time at ..

» 1-Deoxynojirimycin and 1-Deoxyaltronojirimycin
09/02/10 11:02 from TotallySynthetic.com
Davies, Bagal, Lee, Roberts, Russell, Scott, Thomson. Org. Lett., 2009, ASAP. DOI: 10.1021/ol902533b. More of a post-ette than a full post, this tasty little nugget was found buried amongst effective reposts and updates.  Out there to give..

» Nakadomarin A
09/02/10 11:02 from TotallySynthetic.com
Yeah, I've not posted in a bit… Cephalostatin 1 is going into Chemistry World next month, but this months is also worth a read.  Darren Dixon's synthesis of Nakadomarin A contains quite a few interesting transformation, and is very s..

» 9-Isocyanopupukeanane
09/02/10 11:02 from TotallySynthetic.com
Corey, Brown. Org. Lett., 2009, ASAP. DOI: 10.1021/ol9025793.  . Corey, Behforouz, Ishiguro. JACS., 1979, 101, 1608–1609. DOI: 10.1021/ja00500a048.  Again, it's been a while since I blogged, and this time the excuses are two-fold.  First o..

» Addendum - The Vocational Bachelors Degree in Chemistry
09/02/10 10:45 from The Chemportal
The vocational Bachelors degree in Chemistry should be devised for people who wish to obtain their degree and be employed in the industry right away, rather than go on to graduate school.  It is designed to increase ..

» A Final Note On the Merits of a Bachelors degree in Chemistry
09/02/10 10:45 from The Chemportal
Please refer to the previous post to understand where all of this stemmed from. As for the final note on this thread I would like to make a few pointers as well as acknoweldgements based on the comments that have transpired. I should h..

» A Note To All Undergraduates Who Wish To Pursue A Degree In Chemistry
09/02/10 10:45 from The Chemportal
...Academia is obvlious to the industry, there is no official relationship or connection between the two (The following refers to the situation in the state of Georgia.).  Don't enroll in Chemistry unless you plan to go ..

» Exposure to Chemicals and Suicide Rates
09/02/10 10:45 from The Chemportal
At my previous job as an entry level process chemist there were times where people who were "high" on the corporate ladder would visit the pilot lab to assess its development and make certain that the site was properly situated for what wou..

» Grad school “Second Life - style ” . Going to graduate school in New York while in Georgia.
09/02/10 10:45 from The Chemportal
This guy at my workplace is going to grad school in New York while working here in Georgia , the company pays for his tuition and he gets video lecture material all through the net , his major is in chemical engineering , and it seems that ..

» The not so ordinary properties of phosphate buffer
09/02/10 10:45 from The Chemportal
Part of an extraction procedure that's employed requires phosphate buffer as the solvent for one of the steps (extraction procedure is confidential).  Now, I never had problems with it before , and had been making it for several months..

» My final trip back to the University
09/02/10 10:44 from The Chemportal
A few days ago, I took the trip back to the University to have that special talk with the professor once more, so that I could finally obtain the grade for the last of the courses that I took for an ACS certified Bachelors Degree in Chemist..

» Science professors have green and rotting teeth
09/02/10 10:44 from The Chemportal
  Is it because some of them don't smile?  A lot of coffee?  Probably the combination of both .... without brushing their teeth.  Yes , a lot of science professors, especially the old fashioned ones (some of them a..

» The future of biochemistry: the biochemistry of psychology
09/02/10 10:44 from The Chemportal
During the period that one of my last courses, biochemistry, was in session, I remember an occasion where I had stopped by the professor's office to point out an error in the grading of a test.  He was friendly, in a very excitable moo..

» More preferable to Chemists….Nature or Science magazine?
09/02/10 10:44 from The Chemportal
I remember reading Kary Mullis' autobiography and a chapter from this book describing the event of getting a physics article published in Nature , despite the fact that he was a chemist.  Kary Mullis was t..

» Cursed Pine Nuts or Triglycerides?
09/02/10 08:40 from Just Chromatography
A few days ago I noticed that my taste was disturbed: no matter what I eat or drink I feel the bitter taste in my mouth. This bitter, metallic taste appears within seconds of chewing and it affects everything I eat even sweets! Initially I ..

» Forensic Application of Gas Chromatography
09/02/10 08:40 from Just Chromatography
These days gas chromatography (GC) is one of the primary analytical techniques used in every forensic laboratory. GC is widely used by forensic scientists - from analysis of body fluids for the presence of illegal substances, to testing of..

» Heat Flow through Hydrocarbon Chains
09/02/10 08:40 from Just Chromatography
Scientists have measured heat conduction through a monolayer of hydrocarbon chains using a novel technique. Researchers understand heat transfer on the scales of individual molecules and in solids, but there is still much to learn about the..

» Nano LC Sensitivity
09/02/10 08:40 from Just Chromatography
In theory, the analyte sensitivity increases on decreasing the column inner diameter; however, because of the very low sample volumes injected - 20-60 nL, nano liquid chromatography cannot be considered as an analytical method of high sensi..

» “Fast” HPLC better than UHPLC
09/02/10 08:40 from Just Chromatography
Research scientists from Schering-Plough Research Institute developed a rapid high-performance liquid chromatography (HPLC) technique that allows for efficient separation and analysis of pharmaceutical compounds. The method uses a short col..

» Fishy Chromatography
09/02/10 08:40 from Just Chromatography
Folks from India extracted 99.6% pure eicosapentaenoic acid (EPA) using silver ion (argentation) column chromatography from hydrolyzed sardine oil[1]. EPA and DHA (docosahexaenoic acid) are the two main long-chain polyunsaturated fatty aci..

» Columns for Gas Chromatography: Performance and Selection
09/02/10 08:40 from Just Chromatography
Choosing the right column is key in Gas Chromatography. "Columns for Gas Chromatography: Performance and Selection" is a new hands-on reference for scientists and technicians working with packed column and capillary column gas chromatograp..

» Motor Proteins in Nanotechnology
09/02/10 08:40 from Just Chromatography
The biological cell is basically a miniature factory, which contains a large collection of dedicated protein machines. In a Review, Martin van den Heuvel and Cees Dekker look at recent progress in using some of these proteins to move, mani..

» The Little Botanists
09/02/10 08:40 from Just Chromatography
I am continuing the series dedicated to the chromatography??s founder Mikhail Tsvet. So, in 1897 he moves to Russia from Switzerland, and here is his first impression of Russia: "...during the first six months that I have been in Russia, in..

» Unanswered Questions
09/02/10 08:40 from Just Chromatography
Today I studied my blog's statistics to see what keywords people use to search in Google and Yahoo! to get to the pages of my site. Here is what I found based on the last 60 days of statistics: People used 1966 various search terms The top ..