15 Marijuana, the wonder plant, has once again made its way into the scientific literature by helping people, not with cancer, AIDS, or glaucoma, but MRSA type resistant bacterial infections! (It helps everything!) Before we get too far into this, it’s worth noting that smoking marijuana does not actually help the treatment of lung infections, even though the cannabinoids appear to be potent antibiotics. Research has done the concept of smoked marijuana no good. Be that as it may, Giovanni Appendino and Simon Gibbons, present a compelling case that canabanoids may well be effective antibiotics, in particular they are still effective toward “superbugs” or MRSA. In their recent publication (DOI: 10.1021/np8002673) in the Journal of Natural Products, they detail the ass kickity powers of cannabinoids as well as their derivatives against some of the world’s most naughty bacteria.
This is all very good news since it appears that most cannabinoids aren’t toxic at even high doses and injecting people with marijuana could make for some fun hospital shennanigans. The bad(ish) news is that they’re still around an order of magnitude (or thereabouts) worse than antibiotics like erythromycin against regular old pooie bacteria. Nevertheless, the dearth of new antibiotic discoveries makes this a rather welcome one. Now, if people could get over their crippling fear of the REEFER MADDNESS, maybe we can get some serious research done on it.
Giovanni Appendino, Simon Gibbons, Anna Giana, Alberto Pagani, Gianpaolo Grassi, Michael Stavri, Eileen Smith, M. Mukhlesur Rahman (2008). Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study Journal of Natural Products, 71 (8), 1427-1430 DOI: 10.1021/np8002673
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The extreme water-insolubility of neutral cannabinoids makes administration by other than inhaled nebulization somewhat problematic. Azithromycin can really be your puppy! 68-hr half-life and concentated in phagocytes. WBCs go to infected tissue, local azirthromycin concentration zooms 60X over body average.
Offical treatment is 500 mg then 250 mg/day for the next four days. The course that works, as applied in Europe where the stuff was discovered, is 500 mg/500 mg/500 mg. Bolus administration of 4000 mg did not kill volunteers. Contradindicated for those with liver problems.
That boo is non-addictive makes it the fattest target for the War on Drugs. If you cannot get users hooked, where are your business model, parameterized DCF/ROI projections, and PowerPoint 3-D graphics?
“The extreme water-insolubility of neutral cannabinoids makes administration by other than inhaled nebulization somewhat problematic.”
How does this explain the brownies though?
The THC is soluble in the oil you use to make brownies. For best results, grind the plant in the oil, heat the oil in a saucepan (not too hot) and strain with a cheese cloth. You’re welcome.
it can obviously be administered orally
FDA-approved oral cannabinoid analogues for chemotherapy nausea and such, nabilone/Cesamet, are crap compared to the real thing. No IV delivery works either. Compazine is worthless. One is disgusted that cancer chemotherapy can horribly rot a person’s body with full FDA approval butsmoking a joint mandates heinous armed Federal response.
“The most frequent side effects were drowsiness, vertigo, dry mouth, and euphoria.” Euphoria! That’s good for 20 years in jail all by itself (compete with SSRIs, get crunched). “Pain is Christ kissing you,” Mother Teresa. One hopes her husband gave her a full deep frenching.
Uncle Al, do you have any speculation as to the LogP of THC as opposed to cannabinoid derivatives?
After a stint at NIH, how much worse could government be? FDA interfaces. The FDA is corrupt, incompetent, ineffective, unsafe, and ungodly expensive – the FEMA of pharma. The world does not want to be saved.
Oh yeah… THC log(P) (octanol/water) ~ 7 (also reported as 3); pKa = 10.6. See,
http://abstracts.aapspharmaceu.....ionId=1072
Pack a(n engineering) pipe with ethnopharma then discharge butane lighter fluid through it under pressure. Effluent evaporates to give active fractions and waxes (then alumina flash). Don’t pull a Richard Pryor.
The Chemblog’s official “I don’t post unless there are more than 10 comments in the previous thread” is simply my own ego. I’m sorry. It’s just the way it is. I’m an egotistical prick and I do it for the e-love.
god, you are such
a fucking
crybaby
I’m wounded.
I think we are all a little tense after writing long polemics and insulting each other in the last posted topic. Sorry… even a post on cannabinoids can’t get me to relax.
Besides, they smoke and grow marijuana all day long back in the old country, so I’m trying not to pay too much attention to any cannabis-glorified related posts so that I can get away from thinking about the old country too much. Damn useless hippies.
I have been fighting MRSA for 8 years and have only been smoking weed for that long. It was the only thing that helped me to hold down any food or water. Now I have not been really sick for a year now except for when I go without smoking for a week or so. I have been trying to quit but I gotta do what I gotta do to eat and hold it down. It is the only thing that makes me feel better so I can function. I don’t think my MRSA is gone because it was in my blood stream. It was also in my stomach which I had 5 surgerys to remove it. And I hope that is finally gone, because it has not grown back now in over a year. And if people are hurting themselves over smoking weed then they have other serious problems noone knows about.
that is one funny pic lol, that lady must be having a ton of fun.